Objective: To optimize water extracting technology of Jiawei Baiteng granules. Method: Withcomposite score of contents of berberine hydrochloride

paeoniflorin and solid-containing as index

orthogonal test was adopted to optimize extraction process by taking the amount of water

extraction time and boiling times as factors.Contents of berberine hydrochloride and paeoniflorin were determined by HPLC coupled with DAD detector

mobile phase consisted of 10 mmol· L-1 potassium dihydrogen phosphate solution (A)-acetonitrile(B) with gradient elution program of(0-9 min

19.5% B;9-10 min

19.5-45% B;10-25 min

45% B)

detection wavelengths were set at 347 nm and 231 nm

respectively. Result: Optimal extracting technology was as follows:decocted 3 times with 10 times the amount of water for 1 h at each time;under these conditions

contents of berberine hydrochloride

paeoniflorin and solid-containing were 0.092 5 g

0.333 7 g and 23.69%

respectively. Conclusion: This optimizeprocesswas reasonable

feasible and reproducible

which could guide industrial production of Jiawei Baiteng granules.