Objective: To optimize extraction process of immunologically active componentsinAstragali Radix. Method: Taking extracting amounts of astragaloside and total polysaccharides from Astragali Radix

dry extract yieldas comprehensive evaluation index

methods of 1% NaOH soaking

1% CaO boiling and water extraction were investigated by single factor test.HPLC was adopted to determine the content of astragaloside with mobile phase of acetonitrile-water (30:70)

air pump pressure of 0.4 MPa

ELSD drift tube temperature at 105℃ and carrier gas flow rate of 2.7 L· min-1;the content of total polysaccharides from Astragali Radix was determined by UV

detection wavelength was set at 489 nm. Result: By extracting of these three kinds of methods

extracting amounts ofastragaloside were 0.826

1.016

0.842 mg· g-1

extracting amounts oftotal polysaccharides were 14.49

5.82

17.04 mg· g-1

respectively;but dry extract yield had no significant difference. Conclusion: Water extraction process could achieve better extraction effect by comparing with the other two methods

itcould reduce production costs for industrial mass production of immunologically active componentsinAstragali Radix.