五味汤联合吉西他滨顺铂对非小细胞肺癌术后辅助化疗的影响

温士旺; 张月峰; 李勇; 吕会来; 徐延昭; 李振华; 田子强

doi:10.13422/j.cnki.syfjx.2014160184

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五味汤联合吉西他滨顺铂对非小细胞肺癌术后辅助化疗的影响

临床 | 更新时间：2024-01-04

- 五味汤联合吉西他滨顺铂对非小细胞肺癌术后辅助化疗的影响
- Wuwei Tang Combined with Gemcitabine Cisplatin in Non-small Cell Lung Cancer with Postoperative Adjuvant Chemotherapy Curative Effect Observation
- 中国实验方剂学杂志 2014年20卷第16期页码：184-186
- 作者机构：
- 作者简介：
- 基金信息：
  
  河北省卫生厅基金项目（07296）
- DOI：10.13422/j.cnki.syfjx.2014160184
  中图分类号： R734.2
- 纸质出版日期：2014
- 稿件说明：
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温士旺, 张月峰, 李勇, 等. 五味汤联合吉西他滨顺铂对非小细胞肺癌术后辅助化疗的影响[J]. 中国实验方剂学杂志, 2014,20(16):184-186.

WEN Shi-wang, ZHANG Yue-feng, LI Yong, et al. Wuwei Tang Combined with Gemcitabine Cisplatin in Non-small Cell Lung Cancer with Postoperative Adjuvant Chemotherapy Curative Effect Observation[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(16): 184-186.
温士旺, 张月峰, 李勇, 等. 五味汤联合吉西他滨顺铂对非小细胞肺癌术后辅助化疗的影响[J]. 中国实验方剂学杂志, 2014,20(16):184-186. DOI： 10.13422/j.cnki.syfjx.2014160184.

WEN Shi-wang, ZHANG Yue-feng, LI Yong, et al. Wuwei Tang Combined with Gemcitabine Cisplatin in Non-small Cell Lung Cancer with Postoperative Adjuvant Chemotherapy Curative Effect Observation[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(16): 184-186. DOI： 10.13422/j.cnki.syfjx.2014160184.

摘要

目的：探讨中药五味汤联合吉西他滨、顺铂在非小细胞肺癌术后辅助化疗的治疗效果。方法：将84例行手术治疗的非小细胞肺癌患者按照随机分组原则分成治疗组与对照组，每组42例，两组均采取吉西他滨、顺铂方案进行术后辅助化疗，28 d为1个周期，共4个周期，治疗组联合中药五味汤治疗，每日1剂，疗程4个月。化疗结束后观察两组患者近期疗效及药物毒性反应。结果：治疗组客观缓解率及中医证候总有效率均优于对照组（P<0.05），药物毒性反应明显低于对照组（P<0.05）。结论：中药五味汤联合吉西他滨、顺铂用于非小细胞肺癌术后辅助化疗，可显著增强化疗疗效，降低药物毒性反应。

Abstract

Objective: To study the Wuwei tang combined with gemcitabine and cisplatin in the treatment of non-small cell lung cancer with postoperative adjuvant chemotherapy. Method: Eighty-four patients underwent surgical treatment of non-small cell lung cancer were divided into observation group and control group in accordance with the principle of randomization group

42 cases in each group

two groups of gemcitabine and cisplatin scheme is adopted for postoperative adjuvant chemotherapy and 28 days for a cycle

a total of four cycles

observation group of combined therapy with Wuwei tang

daily 1 agent

treatment course for four months. Observe two groups of patients after chemotherapy in the near future curative effect and drug toxicity reaction. Result: The observation group of syndromes was objective response rate and total effective rate were better than control group(P<0.05)

drug toxicity reaction significantly lower than control group (P<0.05). Conclusion: Wuwei tang combined with gemcitabine and cisplatin for non-small cell lung cancer with postoperative adjuvant chemotherapy

can significantly enhance chemotherapy curative effect

reduce drug toxicity reaction.

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