Objective: Observe the clinical effects of Bushen Qiangdu decoction on cure of spinal joint disease(SpA) added western medicine treatment and the serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α). Method: Fifty-eight patients were divided into western medicine group for (28 cases)and observation group for (30 cases).For patients in control group took celecoxib capsules

0.2 g/time

1 does/day

stopped as the pain control.Besides they took leflunomide tablets

20 mg/time

1 does/day

sulfasalazine enteric-coated tablets

1.0 g/time

2 does/day.On the basis of western medicine group treatment

observation group used Bushen Qiangdu decoction for dialectical add and subtract treatment.Both groups' treatment courses were four months.Conducted PAP disease activity index(BASDAI) Bath ankylosing spondylitis functional index(BASFI)

spinal pain Likert four level score and overall assessment four level score from doctor before and after treatment.Graded joint pain

joint swelling and attachment points pain for pre-therapy and post-treatment.Test erythrocyte sedimentation rate (ESR)

C-reactive protein(CRP)

interleukins-6(IL-6) and tumor necrosis factor(TNF-α). Result: After treatment

BASDAI

BASFI

Likert and doctor's overall assessment score for observation group were lower than those data in western medicine group(P<0.01).Patients in observation group'scores of joint pain

joint swelling and attachment points pain were inferior to those data in western medicine group(P<0.01).The level of ESR

CRP

IL-6 and TNF-α for observation group were below to the level in western medicine group after treatment (P<0.01).There were 14 patients(50%) reached ankylosing spondylitis activity score-50 (ASAS50) in western medicine group and 19 patients(63.3%) in observation group.ASAS50 in observation group was higher than that in western medicine group.But there was no obvious statistically difference. Conclusion: Syndrome differentiation treatment of Bushen Qiangdu decoction combined with western medicine in treating spondyloarthropathy can ameliorate pain

swelling et acute symptoms.It was able to improve joint and spine dysfunction and had function of anti-inflammatory and immunoregulation.It can western medicine the disease activity.