Objective: The observe taken orally the Yiqi Huadu decoction which combined with cinobufagin Bladder irrigation to prevent and cure postoperative recurrence of superficial bladder cancer to survey the influence of patients' cellular immune function and vascular endothelial growth factor(VEGF). Method: Ninety patients were randomly divided into western medicine group (45 cases) and observation group (45 cases) by random number method. Both group adopt urinary bladder tumor resection (TUR-BT).After the surgery

the patients in western medicine group took pirarubicin hydrochloride

30 mg/time

once a week

by bladder perfusion

8 times in total.Since then

1 time in a month

10 times in total.Treatment courses were 12 months.Use Huachan hormone injections (30 mL/time)and pirarubicin hydrochloride (30 mg/time)by bladder perfusion for observation group.The methods and treatment were the same as the western medicine group.In the meantime

observation group patients added Yiqi Huadu decoction

one does a day in the first three months.Since then

took a potion in interval one day.The total treatment courses were 12 months.Using B ultrasound and cystoscope et to detect patients' relapse within a year.Adopt flow cytometry instrument method test the level of peripheral blood T lymphocyte subsets(CD3+

CD4+

CD8+和CD4+/CD8+)and natural killer cells(NK) at the third

sixth and twelfth month before and after treatment.Detect the level of vascular endothelial growth factor(VEGF) and record quality of life (KPS) score at the third

sixth and twelfth month before and after treatment.Record adverse reactions

such as nausea

vomiting

abdominal pain

diarrhea

etc.Besides monitor the liver function and blood routine. Result: During one year after operation

numbers of relapsing cases in observation group were 7 and the rate was 15.56%

numbers of relapsing cases in western medicine group were 15

and the rate was 33.33%

and rate of relapsing cases in observation group was lower than in western medicine group(P<0.05).At the sixth mouth after treatment

levels of CD3+

CD4+

CD4+/CD8+ and NK in observation group were higher than those in western medicine group(P<0.01)

and level of CD8+ was lower than in western medicine group(P<0.01).After three mouths of treatment

compared with the time before treatment

score of KPS in observation group decreased(P<0.05)

which in western medicine group was not significant.After three

six and twelve mouths of treatment

scores of KPS in observation group were higher than those in western medicine group(P<0.05

P<0.01).After six and twelve mouths of treatment

levels of serous VEGF in observation group were lower than those in western medicine group(P<0.01).Cumulative happened of adverse reactions in western medicine group were 26 cases

and the rate was 57.7%

cumulative happened of adverse reactions in observation group were 15 cases

and the rate was 33.3%

which in observation group were lower than those in western medicine group(P<0.05). Conclusion: Cinobufacini bladder perfusion combined with oral Yiqi flower and reduce the recurrence of bladder cancer after operation

reduce the adverse reaction induced by chemotherapy

improve the quality of life

and its mechanism may be related to improving cellular immune function of patients

reduce the level of serum VEGF.