Objective: To investigate adsorption kinetics and thermodynamic characteristics of macroporous resin for total triterpenoids from Schizandrae Sphenantherae Fructus

in order to provide a reference for separation and purification of these compounds. Method: With adsorption and elution rate as indexes

optimum type of macroporous resin for purification of total triterpenoids was selected from 11 kinds of macroporous resin by static adsorption and desorption test

then adsorption kinetics model and adsorption isotherm model of total triterpenoids were established by AB-8 resin and calculated thermodynamic parameters. Result: AB-8 resin was selected

resin adsorption processor for total triterpenoids showed fast adsorption stage in 0-50 minutes and slow adsorption stage in 50-200 minutes

adsorption after 200 minutes was saturation stage.Adsorption dynamic behavior was well described by quasi-second-order kinetics equation

adsorption rate was mainly controlled by liquid film diffusion and intraparticle diffusion;equilibrium adsorption data were fitted Freundlich isotherm equation which was belonging to multi-molecular layer adsorption;high temperature was advantageous to adsorption. Conclusion: Adsorption process of AB-8 resin for total triterpenoids was driven by entropy

solid-liquid interface molecular motion was more confusion

more water molecules promiscuously moved from solid surface to solution

which had a certain guiding significance for optimizing purification process of total triterpenoids from Schizandrae Sphenantherae Fructus.