Box-Behnken响应面分析法优化乌苏里瓦韦中绿原酸提取工艺

王丽红; 谭凤田; 赵宏; 姜博

doi:10.13422/j.cnki.syfjx.2014170024

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Box-Behnken响应面分析法优化乌苏里瓦韦中绿原酸提取工艺

工艺与制剂 | 更新时间：2024-01-04

- Box-Behnken响应面分析法优化乌苏里瓦韦中绿原酸提取工艺
- Optimization of Extraction Process for Chlorogenic Acid from by Box-Behnken Response Surface Methodology
- 中国实验方剂学杂志 2014年20卷第17期页码：24-26
- 作者机构：
- 作者简介：
- 基金信息：
  
  黑龙江省教育厅课题（12521529）
- DOI：10.13422/j.cnki.syfjx.2014170024
  中图分类号： R284.2
- 纸质出版日期：2014
- 稿件说明：
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王丽红, 谭凤田, 赵宏, 等. Box-Behnken响应面分析法优化乌苏里瓦韦中绿原酸提取工艺[J]. 中国实验方剂学杂志, 2014,20(17):24-26.

WANG Li-hong, TAN Feng-tian, ZHAO Hong, et al. Optimization of Extraction Process for Chlorogenic Acid from by Box-Behnken Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 24-26.
王丽红, 谭凤田, 赵宏, 等. Box-Behnken响应面分析法优化乌苏里瓦韦中绿原酸提取工艺[J]. 中国实验方剂学杂志, 2014,20(17):24-26. DOI： 10.13422/j.cnki.syfjx.2014170024.

WANG Li-hong, TAN Feng-tian, ZHAO Hong, et al. Optimization of Extraction Process for Chlorogenic Acid from by Box-Behnken Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 24-26. DOI： 10.13422/j.cnki.syfjx.2014170024.

摘要

目的：优选乌苏里瓦韦中绿原酸的提取工艺。方法：在单因素试验基础上，选取料液比、乙醇体积分数、提取时间为自变量，绿原酸提取量为响应值，根据Box-Benhnken试验设计原理，利用响应面分析法优化乌苏里瓦韦中绿原酸的醇提工艺。结果：最佳提取工艺为加68倍量75%乙醇提取2次，每次41 min；绿原酸提取量达8.26 mg·g-1，与理论预测值8.47 mg·g-1偏差较小。结论：醇提法与传统工艺比较，具有提取率高、能耗少、时间短和低成本等特点。优选的工艺稳定可行，为乌苏里瓦韦的工业化生产提供参考。

Abstract

Objective: To optimize extraction process of chlorogenic acid from Lepisorus ussuriensis. Method: On the basis of single factor tests

taking material-liquid ratio

ethanol concentration and extracting time as independent variables

yield of chlorogenic acid in response to a value

according to Box-Benhnken experiment design principle

extraction process of chlorogenic acid from L. ussuriensis was optimized by response surface analysis. Result: Optimum extraction process was as following:extracted twice with 68 times the amount of 75% ethanol for 41 min per time;extracting amount of chlorogenic acid was 8.26 mg·g-1

which was close to the theoretical prediction of 8.47 mg·g-1. Conclusion: Compared with traditional processes

alcohol extraction process had characteristics

such as high extraction efficiency

less energy consumption

low cost

et al.This optimized process was stable and feasible for providing a reference for industrial production of L. ussuriensis.

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