罗布麻总黄酮主要成分在大鼠胃肠吸收的初步探讨

郝旭亮; 张素琼; 刘聪; 李青山; 倪艳

doi:10.13422/j.cnki.syfjx.2014170121

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罗布麻总黄酮主要成分在大鼠胃肠吸收的初步探讨

药物代谢 | 更新时间：2024-01-04

- 罗布麻总黄酮主要成分在大鼠胃肠吸收的初步探讨
- Preliminary Investigation of Gastrointestinal Absorption of Total Flavonoids from Apocyni Veneti Folium in Rats
- 中国实验方剂学杂志 2014年20卷第17期页码：121-124
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81274132）
- DOI：10.13422/j.cnki.syfjx.2014170121
  中图分类号： R285.5
- 纸质出版日期：2014
- 稿件说明：
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郝旭亮, 张素琼, 刘聪, 等. 罗布麻总黄酮主要成分在大鼠胃肠吸收的初步探讨[J]. 中国实验方剂学杂志, 2014,20(17):121-124.

HAO Xu-liang, ZHANG Su-qiong, LIU Cong, et al. Preliminary Investigation of Gastrointestinal Absorption of Total Flavonoids from Apocyni Veneti Folium in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 121-124.
郝旭亮, 张素琼, 刘聪, 等. 罗布麻总黄酮主要成分在大鼠胃肠吸收的初步探讨[J]. 中国实验方剂学杂志, 2014,20(17):121-124. DOI： 10.13422/j.cnki.syfjx.2014170121.

HAO Xu-liang, ZHANG Su-qiong, LIU Cong, et al. Preliminary Investigation of Gastrointestinal Absorption of Total Flavonoids from Apocyni Veneti Folium in Rats[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(17): 121-124. DOI： 10.13422/j.cnki.syfjx.2014170121.

摘要

目的：考察罗布麻总黄酮主要成分在大鼠胃、肠的吸收情况。方法：采用大鼠在体灌流模型，考察罗布麻总黄酮主要成分在大鼠胃、肠内的吸收情况，以金丝桃苷、异槲皮苷为评价指标，采用HPLC测定灌流罗布麻总黄酮前后指标成分的含量变化，计算二者在胃、肠中吸收率，流动相乙腈-0.05%磷酸水（18.5：81.5），流速0.90 mL·min-1，检测波长360 nm。结果：金丝桃苷、异槲皮苷在大鼠胃中2 h的平均吸收率分别为36.92%，36.49%；在大鼠肠中依次为47.70%，48.25%。结论：金丝桃苷和异槲皮苷在大鼠胃、肠部均有吸收，但两成分在肠部的吸收较胃部好，为罗布麻总黄酮的剂型设计和临床合理用药提供参考。

Abstract

Objective: To investigate gastrointestinal absorption of total flavonoids from Apocyni Veneti Folium in rats. Method: Taking rats in situ perfusion model

absorptivity of hyperin and isoquercitrin in gastrointestinal was counted through detecting contents of index components before and after perfused total flavonoids from Apocyni Veneti Folium by HPLC

mobile phase was acetonitrile-0.05% phosphoric acid (18.5:81.5) at a flow rate of 0.90 mL·min-1 and detection wavelength at 360 nm. Result: A verage absorptivity in stomach of hyperin and isoquercitrin were 36.92% and 36.49%

while in intetines were 47.7% and 48.25%

respectively. Conclusion: This study indicated that hyperin and isoquercitrin had good absorptivity in gastronintestinal department

but absorption of the two ingredients in intestines was better than these in stomach

it could provide scientific basis for dosage form design and clinical rational drug of total flavonoids from Apocyni Veneti Folium.

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