Objective: To investigate the effect and mechanism of Longli Pingchuan paste to episodes of pediatric asthma induced airway inflammation. Method: Forty-eight rats were randomly divided into blank group

model group

dexamethasone group(1 mg·kg-1) and Longli Pingchuan paste high

middle and low dose group (74.8

37.4

18.7 g·kg-1)

8 rats each group. Ovalbumin(OVA) was used to copy the rat model of asthma

administration lasted 1 week. The allergic symptoms rhinitis mucosa and lung tissue

pathologic morphological changes between the nasal mucosa and lung tissue of asthmatic rats were observed

and lung tissue inflammation cell apoptosis rate

the expression of proto oncogene Fas mRNA and B cell lymphoma/leukemia-2(Bcl-2) mRNA were detected. Result: In addition to the blank group

other groups showed allergic rhinitis symptoms allergic asthma

and eosnophil infiltration and similar pathologic morplological changer were seen in the nasal mucosa and lung tissue in model group;compared with blank group

the numbers of asthma rats in the model group increased significantly(P<0.01);compared with model group

Longli Pingchuan paste significantly reduced the number of asthma rats(P<0.01);compared with blank group

inflammation cell apoptosis rate was significantly lower in the model group(P<0.01);inflammation cell apoptosis rate was significantly higher than the model group(P<0.05)

positive expression rate of control gene Fas mRNA of proinflammatory cell apoptosis increased significantly(P<0.01)

positive expression rate of control gene Bcl-2 mRNA of inhibiting inflammation cell apoptosis decreased significantly(P<0.01) in lung tissue in Longli Pingchuan paste high and middle dose group. Conclusion: Longli Pingchuan paste can obviously inhibit airway inflammation in asthma rat

the mechanism may be related to promoting inflammation cell apoptosis and reversing Fas/Bvl-2 ratio imbalance.