Objective: Discuss influence of modified Eryin decoction jiawei to glucose fluctuation and impact on oxidative stress and function of vascular endothelium in treating type two diabetes mellitus(T2 DM). Method: Eighty-six patients with T2 DM were randomly divided into control group (43 cases) and observation group (43 cases) by random number table.Patients in control group received repaglinide tablets

1-2 mg/time

3 times/day

and took it at the fifteenth minute before meal.and patients got subcutaneous injection of insulin glargine injection before sleeping.Based on the treatment of control group

patients in observation group added modified Eryin decoction jiawei

1 dose/day.Course of treatment in two groups were both 12 weeks.Before and after treatment

continuous glucoses which including standard deviation of blood glucose level(SDBG)

mean amplitude of glycemic excursions(MAGE)

mean of daily differences(MODD)

and mean postprandial glucose excursion (MPPGE) were monitored;and fasting blood-glucose(FBG)

fasting insulin(FINS)

two hours' postprandial blood glucose(2h PBG) and glycosylated hemoglobin(HbAlc) were detected

and indexes of homeostasis model assessment of insulin resistance(HOMA-IR)

secretion function of pancreas islet B cell and insulin sensitivity(ISI) were calculated.and Levels of methane dicarboxylic aldehyde(MDA)

superoxide dismutase(SOD)

adiponectin(APN)

von willebrand factor(vWF) and nitric oxide(NO) were detected. Result: After treatment

indexes of FBG

2 hPG

HbA1c and HOMA-IR in observation group were lower than those in control group

but indexes of HOMA-IS and ISI were higher than those in control group(P<0.01).and SDBG

MAGE

MODD and MPPGE in observation group were lower than those in control group(P<0.01).levels of APN and NO in observation group were higher than those in control group(P<0.01)

but level of vWF was lower than in control group(P<0.01). And level of SOD in observation group was higher than in control group(P<0.01)

but level of MDA was lower than in control group(P<0.01). Conclusion: Eryin decoction jiawei can reduce blood glucose of patients with T2 DM

Regulate intraday glucose fluctuation

keep stability of blood glucose

ameliorate secretion function of pancreas islet B cell and improve bodies' insulin sensitivity.And it can also relieve oxidative stress and damage of vascular endothelium

delay the onset of diabetes and its complications.