Objective: This study aimed to explore the relationships of procalcitonin(PCT)

high sensitivity C-reactive protein (hs-CRP) and central venous catheter-related bloodstream infections (CRBSI) in the intensive care unit(ICU) by measuring serum PCT and hs-CRP levels

to provide methods of treatment and clinic experience and reduce unnecessary removal of central venous catheter. Method: In 62 cases of suspected CRBSI patients

blood samples were analyzed by enzyme-linked fluorescent assay to determine PCT concentration

and by solid-phase double-antibody sandwich immunoassay test for the detection of hs-CRP concentrations;CRBSI diagnosis relied on the blood sample culture and tip culture methods

then the samples were divided into CRBSI group and non-CRBSI group. Receiver operating curve (ROC) was plotted

and the area under the receiver operating characteristic curve (AUC) was compared. Result: 26 patients were diagnosed as CRBSI

with significantly higher (P<0.01) serum PCT level (11.44±6.92) μg·L-1 and hs-CRP level (124.60±56.30) mg·L-1 than the PCT levels (1.93±3.08) μg·L-1 and hs-CRP levels (62.48±49.38) mg·L-1 in the non-CRBSI group.The area under the curve (AUC) for PCT was 0.929

whereas a cut-off value of 2.5 μg·L-1 provided the best sensitivity and specificity with a value of 92.3% and 80.6%

respectively. In contrast

the AUC for hs-CRP was 0.802

whereas a cut-off value of 86.62 mg·L-1 provided the best sensitivity and specificity with a value of 76.9% and 77.8%

respectively.The area under the ROC curve

sensitivity

specificity

positive predictive value

and negative predictive value in PCT diagnose for CRBSI were higher than those of CRP. Conclusion: The serum PCT and hs-CRP levels could be used as sensitive indicators to monitor the CRBSI patients of ICU.PCT has higher sensitivity and specificity than CRP

hence monitoring the PCT level dynamicly is more conducive to early clinical prevention and treatment.