Objective: The purpose of this study was to evaluate the efficacy and safety of cinobufacini injection on chronic hepatitis B. Method: We searched the cochrane central register of controlled trials (CCTR)

PubMed

CBM

CNKI

VIP databases up to Dec. 2012.The methodological quality assessment and data extraction of the including studies were conducted by two reviewers independently according to the inclusion and exclusion criteria. Meta-analyses were performed for homogeneous studies using RevMan 4.2.10 software. Result: A total of 17 studies involving 1 635 patients met the inclusion criteria. None of the studies enforced allocation concealment and performed blinding. Conclusion: Cinobufacini injection might be effective in normalizing alanine aminotr ansferase(ALT) levels

clearing hepatitis B virus(HBV) DNA

achieving virus seroconversion and improving hepatic fibrosis

without any serious adverse effects. However

the overall combination effect analysis could not be conducted

because the including studies were performed in small sample with low-quality. More evidence is needed to support this analysis.