With the deeply understanding of the disease pathogenesis

particularly the complex ones

multi-target drug design has become a new tendency of drug development. Nowadays

scientists pay more and more attention on traditional Chinese medicine (TCM)

due to its overall regulating characteristics of multi-component and multi-targets. Systematic pharmacological evaluation of the active compounds in Chinese herbal formula and the identification of the corresponding drug targets are the critical issues in the modern research of Chinese materia medica and the TCM. However

the current TCM drug development patterns and strategies have no longer meet the demand of TCM development. Literature researchers found that with the rapid development of systems biology

all kinds of systems biology technology is widely used in Chinese medicine research and development. At the same time

CADD technology shows unique advantages in active ingredients selection

target detection

toxicity prediction

and prescription mechanism exposition in traditional Chinese medicine. The wide application of systems biology and CADD technology

will provide new idea to clarify the mechanism of action of TCM. Hence

this manuscript aims to analyze the current TCM development patterns

review the application of systems biology technology

and CADD technology in the field of traditional Chinese medicine research and development. Base on the review and analysis

a new TCM development strategy that combining systems biology and CADD technology was proposed. This proposed strategy will provide a reference approach to study the complicated theoretical system and achieve modernization of TCM.