多指标全概率评分法优选参芪益气胶囊醇提工艺

牛晓静; 张文鑫; 段晓颖; 刘晓龙

doi:10.13422/j.cnki.syfjx.2014180026

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多指标全概率评分法优选参芪益气胶囊醇提工艺

工艺与制剂 | 更新时间：2024-01-04

- 多指标全概率评分法优选参芪益气胶囊醇提工艺
- Optimization of Extraction Process of Shenqi Yiqi Capsules by Multi-index Test Breakdown Formula Evaluation
- 中国实验方剂学杂志 2014年20卷第18期页码：26-29
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014180026
  中图分类号： R283.6
- 纸质出版日期：2014
- 稿件说明：
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牛晓静, 张文鑫, 段晓颖, 等. 多指标全概率评分法优选参芪益气胶囊醇提工艺[J]. 中国实验方剂学杂志, 2014,20(18):26-29.

NIU Xiao-jing, ZHANG Wen-xin, DUAN Xiao-ying, et al. Optimization of Extraction Process of Shenqi Yiqi Capsules by Multi-index Test Breakdown Formula Evaluation[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(18): 26-29.
牛晓静, 张文鑫, 段晓颖, 等. 多指标全概率评分法优选参芪益气胶囊醇提工艺[J]. 中国实验方剂学杂志, 2014,20(18):26-29. DOI： 10.13422/j.cnki.syfjx.2014180026.

NIU Xiao-jing, ZHANG Wen-xin, DUAN Xiao-ying, et al. Optimization of Extraction Process of Shenqi Yiqi Capsules by Multi-index Test Breakdown Formula Evaluation[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(18): 26-29. DOI： 10.13422/j.cnki.syfjx.2014180026.

摘要

目的：优选参芪益气胶囊的醇提工艺。方法：以人参总皂苷、马钱苷含量和浸膏得率为指标，利用正交试验考察乙醇体积分数、溶剂用量、提取时间及提取次数对醇提工艺的影响，通过全概率评分法确定最佳醇提工艺。采用HPLC测定人参总皂苷及马钱苷含量，流动相分别为乙腈（A）-水（B）梯度洗脱（0~30 min，18.5%A；30~47 min，29%A；47~57 min，29%~40%A；57~65 min，40%~18.5%A），乙腈-水（8：92），检测波长依次为203，240 nm。结果：参芪益气胶囊最佳醇提工艺为加6倍量80%乙醇提取2次，每次2 h；人参总皂苷和马钱苷提取量分别为167.28，319.51 mg，浸膏得率22.54%。结论：采用多指标全概率评分法优选的提取工艺科学、合理，为改善该制剂的临床疗效提供参考。

Abstract

Objective: To optimize alcohol extraction process of Shenqi Yiqi capsules. Method: With dry extract yield

contents of total ginsenosides and loganin as indexes

orthogonal design was carried out for optimizing extraction process by taking the concentration and amount of ethanol

extracting time and times as factors

optimum process was determined by multi-index test breakdown formula evaluation.Contents of total ginsenosides and loganin were determined by HPLC

mobile phase were consisted of acetonitrile(A)-water(B) in gradient elution(0-30 min

18.5%A;30-47 min

29%A;47-57 min

29%-40%A;57-65 min

40%-18.5%A) and acetonitrile-water (8:92)

detection wavelength were set at 203

240 nm

respectively. Result: Optimal alcohol extraction technology was as following:extracted twice with 6 times the amount of 80% ethanol for 2.0 h per time;extracting amounts of total ginsenosides and loganin were 167.28 mg and 319.51 mg

dry extract yield was 22.54%. Conclusion: This optimized extraction process is reasonable and scientific

which can provide a reference for improving clinical efficacy of Shenqi Yiqi capsules.

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