Objective: This study aimed to analyze the relationship between the traditional Chinese medicine (TCM) formula with different proportions and the treatment for diseases by using the method of statistical analysis. Method: Totally 1 557 TCM formulae of rhizoma atractylodis macrocephalae and radices paeoniae alba were retrieved from the ‘Traditional Chinese Medicine Formula Database’

and then a new database was built to analyze the relationship among the ratio

the corresponding cured disease and the department. Result: The ratio of 1:1 appeared to be the most(734 times

47.1%) in the 1 557 formulae containing rhizoma atractylodis macrocephalae and radices paeoniae alba

which was most frequently used for the treatment of the diseases in internal medicines (717 times

46.1%) and gynecology(581 times

37.3%). Conclusion: Using the method of statistical frequency analysis can effectively elucidate the relationship between rhizoma atractylodis macrocephalae and radices paeoniae alba

which can effectively discover the application pattern of the TCM formulae

to provide a theoretical basis for clinical application

also to provide a reference for TCM formulae research as well as new drug research and development.