黄山药化学成分、药理作用及临床应用研究进展

赵叶; 王维皓; 荆文光; 刘安

doi:10.13422/j.cnki.syfjx.2014180235

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黄山药化学成分、药理作用及临床应用研究进展

综述 | 更新时间：2024-01-04

- 黄山药化学成分、药理作用及临床应用研究进展
- Advances on Chemical Constituents, Pharmacological Effects and Clinical Applications of Dioscorea Panthaicae Rhizoma
- 中国实验方剂学杂志 2014年20卷第18期页码：235-242
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家“重大新药创制”科技重大专项（2011ZX09401-028，2011-2013）
- DOI：10.13422/j.cnki.syfjx.2014180235
  中图分类号： R282.71
- 纸质出版日期：2014
- 稿件说明：
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赵叶, 王维皓, 荆文光, 等. 黄山药化学成分、药理作用及临床应用研究进展[J]. 中国实验方剂学杂志, 2014,20(18):235-242.

ZHAO Ye, WANG Wei-hao, JING Wen-guang, et al. Advances on Chemical Constituents, Pharmacological Effects and Clinical Applications of Dioscorea Panthaicae Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(18): 235-242.
赵叶, 王维皓, 荆文光, 等. 黄山药化学成分、药理作用及临床应用研究进展[J]. 中国实验方剂学杂志, 2014,20(18):235-242. DOI： 10.13422/j.cnki.syfjx.2014180235.

ZHAO Ye, WANG Wei-hao, JING Wen-guang, et al. Advances on Chemical Constituents, Pharmacological Effects and Clinical Applications of Dioscorea Panthaicae Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(18): 235-242. DOI： 10.13422/j.cnki.syfjx.2014180235.

摘要

黄山药为我国特有的薯蓣科薯蓣属植物，是国家级（五类）新药地奥心血康的主要药源，该药于2012年获准荷兰上市。本文通过查阅近15年国内外有关黄山药的研究报道，对黄山药化学成分、药理作用以及临床应用进行了综述。对黄山药化学成分研究以甾体皂苷类成分为主，具有治疗心肌缺血、降血脂和抗肿瘤等作用，且临床上对于心肌缺血的应用得到了广泛关注。目前分离得到的甾体皂苷化合物数目还偏少，且药理活性的研究大都集中在薯蓣皂苷上，据此，对黄山药其余甾体皂苷以及其他种类化学成分的发掘和药理活性研究的深度和广度相对匮乏。所以，对其化学成分及药理活性还有待进一步深入研究，以期更好地开发利用。

Abstract

Objective: Dioscorea Panthaica Rhizoma is the main raw material of Diao Xinxuekang

which was approved to sell as drug in Holland in 2012.In this review

researches of the chemical components of D. panthaica

their pharmacological actions and clinical applications were summarized based on the domestic and abroad literatures in past 15 years. The researches of the chemical constituents in D.panthaica focused on steroid saponins

which had curing myocardial ischemia

hypolipidemic and antitumous effecst

and its treatment of myocardial ischemia had drawn widely attention of medical field. Compounds isolated from this herb were less

and only dioscin underwent further researches of pharmacological activities. While the discoveries of the other steroidal saponins and their chemical constituents as well as their pharmacological actions were very scarce. Thereby further research of D. panthaica is worthwhile to fulfill the use of plant resources.

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