喜树碱衍生物CZ48缓释纳米粒的制备及其体外释药特性考察

李思阳; 孔庆新; 王洋

doi:10.13422/j.cnki.syfjx.2014190005

您当前的位置：

首页 >

文章列表页 >

喜树碱衍生物CZ48缓释纳米粒的制备及其体外释药特性考察

工艺与制剂 | 更新时间：2024-01-04

- 喜树碱衍生物CZ48缓释纳米粒的制备及其体外释药特性考察
- Preparation and Release of CZ48 Sustained-release Nanoparticles
- 中国实验方剂学杂志 2014年20卷第19期页码：5-7
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家林业局引进国际先进林业技术项目（2012-4-04）;黑龙江省留学归国基金项目（LC201004）
- DOI：10.13422/j.cnki.syfjx.2014190005
  中图分类号： R944
- 纸质出版日期：2014
- 稿件说明：
移动端阅览
李思阳, 孔庆新, 王洋. 喜树碱衍生物CZ48缓释纳米粒的制备及其体外释药特性考察[J]. 中国实验方剂学杂志, 2014,20(19):5-7.

LI Si-yang, KONG Qing-xin, WANG Yang. Preparation and Release of CZ48 Sustained-release Nanoparticles[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 5-7.
李思阳, 孔庆新, 王洋. 喜树碱衍生物CZ48缓释纳米粒的制备及其体外释药特性考察[J]. 中国实验方剂学杂志, 2014,20(19):5-7. DOI： 10.13422/j.cnki.syfjx.2014190005.

LI Si-yang, KONG Qing-xin, WANG Yang. Preparation and Release of CZ48 Sustained-release Nanoparticles[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 5-7. DOI： 10.13422/j.cnki.syfjx.2014190005.

摘要

目的：制备喜树碱衍生物CZ48缓释纳米粒并考察其体外释药特性。方法：以聚乳酸（PLA）为材料，采用W/O/W 型乳化溶剂挥发法制备CZ48缓释纳米粒，通过透射电子显微镜观察纳米粒的微观形态，采用粒度分析仪测定粒径并考察该制剂的体外释药特性。结果：CZ48缓释纳米粒呈明显的球状结构，粒度（260.6±3.2）nm，载药量（11.8±1.29）%，包封率（88.7±2.55）%，体外释放可持续48 h，累积释放率达85%。结论：制备的CZ48缓释纳米粒包封率和载药量高，缓释效果明显，为该制剂的药代动力学研究提供数据支持。

Abstract

Objective: To prepare CZ48 sustained-release nanoparticles and investigate its in vitro release. Method: Using polylactic acid(PLA) as material

CZ48 sustained-release nanoparticles was prepared through W/O/W double emulsion technique

its micromorphology was observed by transmission electron microscope

particle size was determined by particle size analyzer and in vitro release was investigated. Result: CZ48 sustained-release nanoparticles showed obvious spherical structure with particle size of (260.6±3.2)nm

encapsulation efficiency of (88.7±2.55)% and drug-loading of (11.8±1.29)%

in vitro release studies showed that 85% of CZ48 was released from sustained-release nanoparticles in the first 48 h. Conclusion: These prepared CZ48 sustained-release nanoparticles are successfully prepared through W/O/W double emulsion technique with satisfactory encapsulation efficiency and drug-loading and obvious sustained-release

which provides data support for further research on pharmacokinetic.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

葛根素微乳凝胶的制备及体外释放考察

三清降糖方总苷缓释片的制备及其体内外相关性分析

贯叶连翘提取物缓释片的处方工艺优选

Box-Behnken设计-效应面法优化罗布麻压制包衣脉冲片的处方工艺

吸波面积法测定乌头二元释药颗粒的体外释放度