Objective: To clarify the rationality of traditional Chinese medicine after processing and to provide references for using rational them in the clinic

the pharmacodynamic differences of raw Corydalis Rhizoma and vinegar Corydalis Rhizoma based on the theory of crude and cooked traditional Chinese medicine decoction pieces using in different ways advocated by ZHANG Zhong-jing was investigated respectively. Method: By mice hot-board and acetic-acid-induced twisting experiments

the analgesic effect of raw Corydalis Rhizoma and vinegar Corydalis Rhizoma was observed. By mice auricular swelling model by injecting xylene in the abdomen of mice

the anti-inflammation effect of raw Corydalis Rhizoma and vinegar Corydalis Rhizoma on kunming mouse was observed;by the contractile activity on isolated rat small intestine smooth muscle

the spasmolysis effect of raw Corydalis Rhizoma and vinegar Corydalis Rhizoma on Wistar rat was observed;by turbidimetry method

the anti-platelet aggregation effect induced by ADP or collagen on Wistar rat was observed. Result: Compared to blank group

raw Corydalis Rhizoma and vinegar Corydalis Rhizoma for the analgesic effects caused by the heat conduction and chemical stimulation had obvious difference

and there were also obvious difference between raw Corydalis Rhizoma and vinegar Corydalis Rhizoma(P<0.05

P<0.01). Compared to blank group

raw Corydalis Rhizoma and vinegar Corydalis Rhizoma could inhibit the swelling degrees induced by injecting xylene (P<0.01)

but there were no difference between raw Corydalis Rhizoma and vinegar Corydalis Rhizoma;compared to raw Corydalis Rhizoma

vinegar Corydalis Rhizoma could inhibit the contractile activity of isolated rat small intestine smooth muscle (P<0.05

P<0.01). There were no difference between raw Corydalis Rhizoma and vinegar Corydalis Rhizoma on anti-platelet aggregation induced by ADP and collagen. Conclusion: It indicates that Corydalis Rhizoma after processing with vinegar can improve analgesic and spasmolysis effects

corresponding the Chinese medicine processing regulation that the Chinese medicine after processing can increase effects of raw drugs. Using vinegar Corydalis Rhizoma in prescriptions can strengthen analgesic and spasmolysis effects for pain symptoms in the clinic.