Objective: To investigate effect and mechanism of new Weinaian preparation (NWP) on the rat chronic superfical gastritis(CSG) induced by iodoacetamide. Method: SD rats were randomly divided into normal control group(NC

n=10)

CSG group(n=15)

NWP(9.10

2.87

0.91 g·kg-1) groups(n=15

respectively)and Weinaian capsule group (n=15). The CSG rats were induced by 0.1% iodoacetamide for 3 weeks

the drug groups were given by gavage once a day for 3 weeks with appropriate drugs simultaneously

and the nomal contral and CSG groups were given the same amount of water.The effects of NWP on the CSG rats were evaluated by naked eye

pathological section and transmission electron microscope. The action mechanism of Weinaian was studied by detection the level of malondialdehyde(MDA) and superoxide dismutase(SOD) in the rat gastric mucosal. Result: Contrasted with the NC group

there was obvious injury and inflammation cell in the gastric mucosa of the CSG group. The effects of anti-injury were found in the ranitidine and high-dose group of Weinaian groups (P<0.01)

there was dose-reponse relationship in the three Weinaian groups. The ultrastructure injury of chief and parietal cell were improved by the high-dose group of Weinaian.The group also reduced the level of MDA and increased the activity of SOD in the gastric mucosa(P<0.01

vs CSG group). Conclusion: The new Weinaian preparation can alleviate the gastric mucosal injury of CSG rat induced by iodoacetamide which maybe related to clearing gasrica mucosa radical.