Objective: The aim of this study was to observe the effects of pomegranate ellagic polyphenol (PEP)on pacreatic islet function of diabetes mice. Method: Streptozotocin was intraperitoneally injected to induce diabetes in mice

and the diabetes mice were randomly divided into model group

low-dose PEP group

high-dose PEP group and glibenclamide group

while normal mice were taken as control group. PEP was intragastricly administrated for 30 d

body weight

fasting blood glucose

sugar tolerance were tested

HE and immunohistochemistry pancreas slice were made to observe pathohistological changes and expression of transcription factor pancreatic duodenal homeobox-1(PDX-1). Result: Compared with diabetes mice

in mice with PEP administration

the body weight

pacreatic islet area and PDX-1 expression increased

while the fasting blood glucose decreased(P<0.05). Conclusion: PEP has a certain degree of effect on the improvement of pacreatic islet function in diabetes mice

and the machanism might be involved in upregulating the expression of protein PDX-1.