补肾活血开窍方对糖尿病所致血管性轻度认知功能障碍(肾虚血瘀型)的二级预防研究

赵欢; 郭强; 杨东东; 史敏

doi:10.13422/j.cnki.syfjx.2014190181

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补肾活血开窍方对糖尿病所致血管性轻度认知功能障碍(肾虚血瘀型)的二级预防研究

临床 | 更新时间：2024-01-04

- 补肾活血开窍方对糖尿病所致血管性轻度认知功能障碍(肾虚血瘀型)的二级预防研究
- Bushen Huoxue Kaiqiao Fang for Diabetes-induced Vascular Mild Cognitive Impairment(Kidney Deficiency and Blood Stasis) Secondary Prevention
- 中国实验方剂学杂志 2014年20卷第19期页码：181-184
- 作者机构：
- 作者简介：
- 基金信息：
  
  四川省中医药管理局项目（CSZYJ2011016）
- DOI：10.13422/j.cnki.syfjx.2014190181
  中图分类号： R259
- 纸质出版日期：2014
- 稿件说明：
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赵欢, 郭强, 杨东东, 等. 补肾活血开窍方对糖尿病所致血管性轻度认知功能障碍(肾虚血瘀型)的二级预防研究[J]. 中国实验方剂学杂志, 2014,20(19):181-184.

ZHAO Huan, GUO Qiang, YANG Dong-dong, et al. Bushen Huoxue Kaiqiao Fang for Diabetes-induced Vascular Mild Cognitive Impairment(Kidney Deficiency and Blood Stasis) Secondary Prevention[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 181-184.
赵欢, 郭强, 杨东东, 等. 补肾活血开窍方对糖尿病所致血管性轻度认知功能障碍(肾虚血瘀型)的二级预防研究[J]. 中国实验方剂学杂志, 2014,20(19):181-184. DOI： 10.13422/j.cnki.syfjx.2014190181.

ZHAO Huan, GUO Qiang, YANG Dong-dong, et al. Bushen Huoxue Kaiqiao Fang for Diabetes-induced Vascular Mild Cognitive Impairment(Kidney Deficiency and Blood Stasis) Secondary Prevention[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 181-184. DOI： 10.13422/j.cnki.syfjx.2014190181.

摘要

目的：观察补肾活血开窍方在糖尿病所致血管性轻度认知功能障碍（肾虚血瘀型）二级预防中的临床疗效及安全性。方法：将85例糖尿病所致血管性轻度认知功能障碍的患者随机分为治疗组（43例）和对照组（42例），治疗组予以补肾活血开窍方（肉苁蓉10 g，石菖蒲5 g，三七2.5 g）免煎制剂治疗，每天3次口服同时予以基础用药阿司匹林100 mg，每日1次口服；对照组予基础用药阿司匹林100 mg，每日1次口服，上述治疗持续6个月，治疗结束后每6个月进行1次随访，持续至治疗结束后12个月。分别采用日常生活能力量表（ADL）、蒙特利尔认知评估北京版（MoCA）、P300及中医症状评分进行评估。结果：经重复测量资料的方差分析，两组治疗后不同时期的ADL量表、MoCA量表、P300及中医症状评分优于治疗前，其差异均有统计学意义（P<0.05），两组治疗后、治疗结束后6个月随访的ADL量表、MoCA量表、P300及中医症状评分量表评分分别与对照组比较，其差异无统计学意义；治疗结束后12个月随访的ADL量表、MoCA量表、P300及中医症状评分量表评分分别与对照组比较，其差异有统计学意义（P<0.01）。两组不良事件发生率经χ2检验比较无统计学意义。结论：补肾活血开窍方能有效的预防糖尿病所致血管性认知功能障碍继续发展，延缓其自然病程，并且能提高患者的日常生活能力、改善患者的认知功能及中医症状。

Abstract

Objective: This study aimed to observe the clinical efficacy and safety of Bushen Huoxue Kaiqiao fang in the secondary prevention of the diabetes-induced vascular mild cognitive impairment (kidney deficiency and blood stasis). Method: Eighty-five cases of diabetes-induced vascular mild cognitive impairment were randomly divided into treatment group (43 cases) and control group (42 cases). The treatment group received the Bushen Huoxue Kaiqiao fang treatment three times a day orally and an oral administration of aspirin 100 mg once daily

while the control group were given oral administration of aspirin 100 mg once daily alone. The treatment continued for six months

every 6 months after the treatment there was a follow-up study till 12 months after the treatment.Daily living scale (ADL)

Montreal Cognitive Assessment Beijing Edition (MoCA)

P300 and traditional Chinese medicine(TCM) symptom scores were used for evaluation. Result: The variance analysis of repeated measurements analysis of variance revealed that

in both groups

the ADL scale

MoCA scale

P300 and TCM symptom score after treatment were all better than those before treatment at different periods

with the differencesstatistically significant (P<0.05). However

as for the comparison between treatment group and control group

there was no statistically significant difference in both sharply after the treatment and 6 months after the treatment

by t test of ADL scale

MoCA scale

P300 and TCM symptom rating scale scores;while the ADL scale

MoCA scale

P300 and TCM symptom rating scale scores of treatment group all showed statistically significant difference (P<0.01) between sharply after the treatment and 12 months after the treatment

compared with the control group. The incidence of adverse events in both groups showed no statistical significance by χ2 test. Conclusion: Bushen Huoxue Kaiqiao fang can only effectively prevent diabetes-induced vascular cognitive dysfunction continuing to develop

delaying its natural course of the disease

and can improve the patient's activities of daily living

cognitive function and clinical symptoms.

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