Objective: This study aimed to observe the effect of Jiangtang Baoxin pill on the inflammatory factors and endothelial function in patients with type 2 diabetes(T2DM)and unstable angina pectoris(UAP). Method: Seventy-eight patients with T2DM and UAP were randomly divided into two groups:the control group (40 cases) was given conventional therapy;the observation group(38 cases) was given Jiangtang Baoxin pill(6 grams once

three times daily)in addition to conventional treatment. These patients of two groups were treated for 6 months. At the same time

30 healthy people were selected as the healthy control group. Lipids

inflammation and endothelial function indicators were detected before and after treatment

clinical efficacy in patients of two groups were observed before and after 6 months of treatment

cardiovascular events were followed up for 6 months. Result: After 6 months of treatment

the total efficacy of the observation group was significantly higher than that of the control group(P<0.05);the levels ofinterleukin-6(IL-6)

tumor necrosis factor-α(TNF-α)

matrix metalloproteinase 9(MMP-9)

high-sensitivity C-reactive protein(hs-CRP)of patients in the observation group were significantly lower than those in the control group(all P<0.01);the improvement of low-density lipoprotein-cholesterol(LDL-C)

triacylglycerol(TG)

nitric oxide(NO)

endothelin-1(ET-1) in the observation group were significantly better than those of the control group(all P<0.01);Incidence of cardiovascular events of the observation group was significantly lower than that of the control group within 6 months(P<0.05). There was no adverse reaction associated with Jiangtang Baoxin pill in the observation group within 6 months. Conclusion: It was safe and effective that Jiangtang Baoxin pill can be used in the treatment of patients with T2DM and UAP

in which the antagonism of inflammatory reaction and improvement of endothelial function may be one of the mechanisms.