Objective: To discuss the influence of Fuzheng Huadu decoction on hypercoagulable state by assessing blood coagulation factor

platelet activity

blood fat and hemorheology in patients with diabetic kidney disease(DKD) undergoing maintenance hemodialysis. Method: Ninety-six patients with DKD and uremic were randomly divided into control group and observation group of 48 patients each. All patients received basic therapy of conventional and supportive treatment. Patients in control group took oral 5 g Niaodu Qing granules 4 times daily. Patients in observation group took oral Fuzheng Huadu decoction 1 dose daily. All patients in two groups received one 4 month periods of treatment. The levels of fibrinogen(FIB)

maximum aggregation rate (MPAR)

D-dimer (D-D)

von willebrand factor (vWF)

thromboxane B2 (TXB2)

6-Ketone-prostaglandin F1a (6-Keto-PGF1a) and platelet α-glair of membrane particle (GMP-140) were detected. Also

hemorheology indexes and levels of total cholesterol (TC)

triglyceride (TG)

high-density lipoprotein cholesterol (HDL-C)

low-density lipoprotein cholesterol(LDL-C) were detected before and after treatment.Result: After treatment

the level of 6-keto-PGF1a in observation group was higher than that in control group

and levels of TXB2

MPAR and GMP-140 were lower than those in control group (P<0.01). The levels of D-D

FIB and vWF were lower than those in control group (P<0.01). Ameliorate of whole blood viscosity (high and low shear)

plasma viscosity

hematokrit and erythrocyte sedimentation rate were superior to those in control group (P<0.01). The levels of TC

TG and LDL-C in observation group were lower

and the level of HDL-C was higher than in control group (P<0.01). Conclusion: Fuzheng Huadu decoction can improve hypercoagulable state in patients with DKD undergoing maintenance hemodialysis. This effect is likely mediated by reducing promote clotting factor

inhibiting platelet activity

regulating lipid metabolism

preventing thrombus formation and improving microcirculation in patients.