二十五味珊瑚丸联合针灸治疗偏头痛55例

顾鸿

doi:10.13422/j.cnki.syfjx.2014190210

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二十五味珊瑚丸联合针灸治疗偏头痛55例

临床 | 更新时间：2024-01-04

- 二十五味珊瑚丸联合针灸治疗偏头痛55例
- Clinical Observation of Ershi Wuwei Shanhu Pills Combined with Acupuncture on Migraine with 55 Cases
- 中国实验方剂学杂志 2014年20卷第19期页码：210-213
- 作者机构：
- 作者简介：
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- DOI：10.13422/j.cnki.syfjx.2014190210
  中图分类号： R277.7
- 纸质出版日期：2014
- 稿件说明：
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顾鸿. 二十五味珊瑚丸联合针灸治疗偏头痛55例[J]. 中国实验方剂学杂志, 2014,20(19):210-213.

GU Hong. Clinical Observation of Ershi Wuwei Shanhu Pills Combined with Acupuncture on Migraine with 55 Cases[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 210-213.
顾鸿. 二十五味珊瑚丸联合针灸治疗偏头痛55例[J]. 中国实验方剂学杂志, 2014,20(19):210-213. DOI： 10.13422/j.cnki.syfjx.2014190210.

GU Hong. Clinical Observation of Ershi Wuwei Shanhu Pills Combined with Acupuncture on Migraine with 55 Cases[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(19): 210-213. DOI： 10.13422/j.cnki.syfjx.2014190210.

摘要

目的：二十五味珊瑚丸联合针灸治疗偏头痛的临床疗效评价及作用机制的探讨。方法：将110例偏头痛患者随机按数字表法分为观察组和针灸组各55例。针灸组采用针灸治疗，观察组采用二十五味珊瑚丸联合针灸治疗。两组疗程均为6周。观察治疗前后偏头痛发作次数、发作程度、发作天数及伴随症状情况；记录用药前和干预后2，12，24，36，48，60，72 h视觉模拟评分法（VAS）；采用经颅多普勒（TCD）检测治疗前后脑血流速度；检测治疗前后血β-内啡肽（β-EP），内皮素（ET），5-羟色胺（5-HT）和一氧化氮（NO）水平。结果：治疗后2 h两组VAS评分显著下降（P<0.01），治疗后12，24，36，48，60，72 h两组VAS评分均呈下降趋势；观察在72 h时点VAS评分低于针灸组（P<0.05）；治疗后观察组头痛发作次数、发作程度、发作天数、伴随症状评分和总分均低于针灸组（P<0.01）；观察组大脑中动脉（MCA）、大脑前动脉（ACA）、大脑后动脉（PCA）、椎动脉的颅内段（VA）和基底动脉（BA）的流速度均低于针灸组（P<0.01）；观察组β-EP，NO和5-HT水平高于针灸组，ET水平低于针灸组（P<0.01）；观察组疾病疗效总有效率为94.5%，优于针灸组的80%（P<0.05）。结论：二十五味珊瑚丸联合针灸治疗偏头痛临床疗效显著，其作用机制可能与升高β-EP，NO和5-HT，降低ET水平和改善大脑血流速度有关。

Abstract

Objective: Clinical curative efficacy and mechanism of action of Ershi Wuwei Shanhu pills combined with acupuncture in treating migraine were investigated. Method: One hundred and ten patients with migraine were randomly divided into control group and observation group (55 cases

respectively) by random number table. Patients in control group received treatment of acupuncture

and patients in observation group received Ershi Wuwei Shanhu pills and acupuncture. Course of treatment in two groups were both 5 weeks. Frequency of headache attack

degree of headache

days of headache and accompanied symptoms were observed before and after treatment. Visual analogue scales were recorded before treatment and at the 2

72 h after treatment. Cerebral blood flow velocity was detected by transcranial Doppler (TCD) before and after treatment. And levels of β-endorphin (β-EP)

endothelin(ET)

5-hydroxytryptamine(5-HT) and nitric oxide(NO) in serum were detected. Result: VAS scores in two groups decreased significantly at the 2nd hour after treatment(P<0.01)

and there was a decline of VAS scores in two groups at the 12

72 h after treatment. VAS score in observation group was lower than in control group at the 72 nd hour after treatment (P<0.05).Scores of times of headache attack

degree of headache

days of headache and accompanied symptoms of headache and total scores in observation group were all lower than those in control group(P<0.01).Coronary flow velocity of middle cerebral artery(MCA)

anterior cerebral artery(ACA)

posterior cerebral artery(PCA)

vertebral artery(VA) and basilar artery(BA) were all lower than those in control group(P<0.01). Levels of β-EP

NO and 5-HT in observation group were higher than those in control group and level of ET was lower than in control group(P<0.01).The total effective rate in observation group was 94.5%

which is superior to that in control group 84%(P<0.05). Conclusion: Ershi Wuwei Shanhu pills combined with acupuncture had obvious curative efficacy in treating migraine

the mechanism may be related to improving levels of β-EP

NO and 5-HT

reducing level of ET

and ameliorating brains'blood flow velocity.

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