Objective: The aim of the study was to evaluate the effectiveness of Xipayi Mouth Rinse in the treatment of simple gingivitis. Method: We systemically searched China National Knowledge Infrastructure (CNKI)(1979—2012)

Weipu Database for Chinese Technical Periodicals (1989—2013)

PubMed and Cochrane Library.The methodological quality of the included trials was assessed based on the Jadad scale and the available data were analyzed with RevMan software (version 5.2.0). Result: A total of 6 studies involving 490 participants satisfied the minimum criteria for Meta-analysis.The evidence showed that the Xipayi Mouth Rinse was compared with placebo for treatment of simple gingivitis sulcus bleeding index(SBI)[WMD=-0.59

95%CI(-0.76

-0.42)]

plaque index(PLI)[WMD=-0.67

95%CI(-1.03

-0.30)];the Xipayi Mouth Rinse was compared with western medicine for treatment of simple gingivitis [WMD=-0.02

95%CI(-0.14

0.10)]

PLI[WMD=0.03

95%CI(-0.24

0.30)]. Conclusion: The current clinical evidence showed that the effectiveness of Xipayi Mouth Rinse in the treatment of simple gingivitis higher than the Placebo

similar effects with western medicine. Bedides

it can reduce the sulcus bleeding index and plaque index with no significant side effects

and it is easy to take. However

due to the low quality studies and small sample

it is still need to be confirmed by the high-quality

multi-center

large sample

randomized

double-blind clinical controlled trials.