The related issues on the development of Chinese innovative drugs were mainly discussed in this paper. The author argued that 1) the breakthrough point of Chinese innovative drugs should focused on the Chinese clinical practice;2) the combination of component or composition derived from Chinese medicine may be an important research direction but can not substitute the compatibility of Chinese pieces;3) the research on the component combination under the guidance of the traditional Chinese medical theory can apply to medical therapy following syndrome differentiation

whose purpose is to enhance drug safety

clinical suitability

and to use drugs with clear ingredients and action mechanisms

for more stable and controllable product quality for commercial production.So the way the component combination founctions still relies on the multi-components

multi-targets and multiplex regulation.Chinese medicine should not blindly pursue and meet the international standards but to establish its own characteristicquality standards. The serve target of Chinese innovative drugs should focus on Chinese people.