Objective: To investigate influencing factors of kneading method for preparing solid dispersions of water-insoluble drugs by dissolution test under condition of supersaturation.Stability and formulation of solid dispersions were also studied preliminarily. Method: Indomethacin was selected as model drug

solid dispersions were prepared by kneading method

impacts of carrier types

kneading solvent and time on dissolution effects were investigated by single factor tests.Indomethacin solid dispersions were characterized by powder X-ray diffraction;stability test was performed under condition of 40 ℃ and relative humidity of 75% in an environmental test chamber;solid dispersions was formulated in a tablet dosage form by direct compression method. Result: Indomethacin solid dispersions were prepared with poloxamer 188 as a carrier

ethanol-water(1:1) as kneading solvent and kneading time of 30 minutes

which performed well in dissolution test and the maximum solution concentration was 29 times that of indomethacin material;solid dispersions was stable within one month under these test condition;these compressed solid dispersion tablets were bright and clean

whose parameters fitted the standard of 2010 edition of 〈Chinese Pharmacopoeia〉. Conclusion: Dissolution of solid dispersions can be enhanced to a great extent by kneading method

they can easily compress to tablets by direct compression method.