Objective: To optimize molding technology of Qigui dropping pills. Method: Taking dissolution time of dropping pills

pill weight coefficient of variation

appearance score(roundness

hardness

color) as a comprehensive assessment index

based on single factor tests

orthogonal test was adopted to optimize molding technology by taking proportion of drug extract-matrix

dropping distance

material temperature and dropping speed as factors. Result: The best molding technology of Qigui dropping pills was as following:with polyethylene glycol 4000 as matrix

proportion of drug extract-matrix 1:2

material temperature 85 ℃

dropping speed of 45 d·min-1

dropping distance of 9 cm

with atolin as coolant

cooling column length of 110 cm

coolant temperature at 12 ℃;dissolution time was 5.02 min

pill weight difference was less than 10%. Conclusion: This optimized molding technology is stable and feasible.These prepared Qigui dropping pills have high molding rate to meet quality requirements of dropping pills.