Objective: To optimize extraction technology of Fufang Guangjinqiancao granules. Method: With composite score of contents of schaftoside and total flavonoids

yield of dry extract as index

orthogonal test was adopted to optimize water extraction technology by taking the amount of water

extracting time and temperature as factors;taking composite score of contents of total polysaccharides and total flavonoids

removal rate of impurity as index

alcohol precipitation process of water extract was optimized by orthogonal test.With composite score of contents of 23-acetyl alisol B and total flavonoids

yield of dry extract as index

alcohol extraction technology of this compound was optimized by orthogonal test.Contents of schaftoside and 23-acetyl alisol B were determined by UPLC

mobile phase were methanol-0.4% phosphoric acid solution(32:68) and acetonitrile-water(73:27)

respectively;UV was employed to measure contents of total flavonoids and total polysaccharides. Result: Optimum water extraction conditions were as follows:extracted 3 times with 8-folds of water for 1.5 h each time;optimal alcohol precipitation process was:alcohol precipitation concentration 60%

initial density of water extract 1.0 g·mL-1

alcohol sedimentation time for 8 h;optimum alcohol extraction conditions were as follows:extracted 2 times with 8

6-folds of 60% ethanol

extracting time of 1.0

0.5 h

respectively. Conclusion: These optimized extraction processes are stable

feasible and suitable for industrial production of Fufang Guangjinqiancao granules.