银杏叶提取物注射液联合多奈呱齐治疗血管性痴呆的疗效及作用机制

于广娜

doi:10.13422/j.cnki.syfjx.2014200210

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银杏叶提取物注射液联合多奈呱齐治疗血管性痴呆的疗效及作用机制

临床 | 更新时间：2024-01-04

- 银杏叶提取物注射液联合多奈呱齐治疗血管性痴呆的疗效及作用机制
- Curative Effect on Vascular Dementia Disease and Mechanism of Action of Extract of Ginkgo Biloba Injection Combined with Donepezil
- 中国实验方剂学杂志 2014年20卷第20期页码：210-213
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- DOI：10.13422/j.cnki.syfjx.2014200210
  中图分类号： R277.7
- 纸质出版日期：2014
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于广娜. 银杏叶提取物注射液联合多奈呱齐治疗血管性痴呆的疗效及作用机制[J]. 中国实验方剂学杂志, 2014,20(20):210-213.

YU Guang-na. Curative Effect on Vascular Dementia Disease and Mechanism of Action of Extract of Ginkgo Biloba Injection Combined with Donepezil[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(20): 210-213.
于广娜. 银杏叶提取物注射液联合多奈呱齐治疗血管性痴呆的疗效及作用机制[J]. 中国实验方剂学杂志, 2014,20(20):210-213. DOI： 10.13422/j.cnki.syfjx.2014200210.

YU Guang-na. Curative Effect on Vascular Dementia Disease and Mechanism of Action of Extract of Ginkgo Biloba Injection Combined with Donepezil[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(20): 210-213. DOI： 10.13422/j.cnki.syfjx.2014200210.

摘要

目的：探讨银杏叶提取物注射液联合盐酸多奈呱齐片治疗血管性痴呆（VD）的疗效及其抗氧化、改善血管内皮功能、改善脑血流动力的作用。方法：将70例VD患者随机按数字表法分为对照组和观察组各35例。对照组采用盐酸多奈哌齐片，10 mg ·d-1，口服，连续服用3个月。观察组在对照组治疗的基础上采用银杏叶提取物注射液，20 mL/次，静脉滴注，2次/d，连续使用10 d，休息5 d后进行下1个疗程，共6个疗程。进行治疗前后日常生活功能量表（ADL）、血管性痴呆辨证量表（DSVD）和简易精神状态量表（MMSE）评分；检测治疗前后血清内皮素（ET）、一氧化氮（NO）、超氧化物歧化酶（SOD）和丙二醛（MDA）水平；采用经颅多普勒仪检测治疗前后大脑前动脉（ACA）和大脑中动脉（MCA）平均血流速度和搏动指数。结果：观察组认知能力疗效总有效率为77.14%，对照组为51.43%，观察组优于对照组（P<0.05）；观察组日常生活能力疗效总有效率为80%，对照组为57.14%，观察组优于对照组（P<0.05）；治疗后观察组ADL和MMSE评分高于对照组，DSVD评分低于对照组（P<0.01）；治疗后观察组NO，ET和MDA水平低于对照组，SOD水平高于对照组（P<0.01）；治疗后观察组ACA和MCA平均血流速度高于对照组（P<0.01）；两组ACA和MCA搏动指数有减缓趋势，但变化无统计学意义。结论：银杏叶提取物注射液联合多奈呱齐能改善VD患者生活能力、认识能力，其作用机制可能与改善血管内皮功能，抗氧化及自由基损伤，促进脑血流动力有关。

Abstract

Objective: To observe the curative effect of extract of ginkgo biloba injection combined with donepezil in treating vascular dementia (VD) and to explore its effect on anti-oxidation activity

vascular endothelial function and cerebral hemodynamics. Method: Seventy patients with VD were randomly divided into control group and observation group of 35 patients each by random number table. Patients in control group took 10 mg donepezil hydrochloride tablets orally daily for 3 months. Based on the treatment of control group

patients in observation group added extract of ginkgo biloba injection intravenous drip

20 mL/time

twice daily for six 10 days courses of treatment separated by 5 days without treatment. Scores of activities of daily living (ADL)

digital simultaneous voice and data (DSVD) and mini-mental state examination were graded before and after treatment. Levels of serous endothelin (ET)

nitric oxide (NO)

superoxide dismutase (SOD) and malonaldehyde (MDA) were detected. Average blood velocities of arteria cerebri anterior (ACA) and middle cerebral artery (MCA) pulsatility index were detected by transcranial doppler. Result: The total effective rate of cognitive ability in observation group was 77.14%

which is superior to that in control group 51.43%(P<0.05). The total effective rate of activity of daily living in observation group was 80%

which is superior to that in control group 57.14%(P<0.05). Grades of ADL and MMSE in observation group were higher

and grade of DSVD was lower than those in control group after treatment (P<0.01). Levels of NO

ET and MDA in observation group were lower than those in control group

level of SOD was higher than that in control group (P<0.01). Average blood velocities of ACA and MCA in observation group were higher than those in control group (P<0.01). ACA and MCA pulsatility index in both groups had a decreasing trend

but there was no statistically significancent difference. Conclusion: Extract of ginkgo biloba injection combined with donepezil can improve the ability of living and understanding of patients with VD. Its mechanism of action may be relevant to ameliorating endothelial function

anti-oxidation and preventing free radical damage

promoting cerebral hemodynamics.

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