坤泰胶囊对更年期综合征患者性激素及血脂的影响

关素珍; 蒋赟

doi:10.13422/j.cnki.syfjx.2014200218

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坤泰胶囊对更年期综合征患者性激素及血脂的影响

临床 | 更新时间：2024-01-04

- 坤泰胶囊对更年期综合征患者性激素及血脂的影响
- Influence of Kuntai Capsules on Sex Hormone and Blood Fat in Patients with Climacteric Syndrome
- 中国实验方剂学杂志 2014年20卷第20期页码：218-221
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- DOI：10.13422/j.cnki.syfjx.2014200218
  中图分类号： R271.116
- 纸质出版日期：2014
- 稿件说明：
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关素珍, 蒋赟. 坤泰胶囊对更年期综合征患者性激素及血脂的影响[J]. 中国实验方剂学杂志, 2014,20(20):218-221.

GUAN Su-zhen, JIANG Yun. Influence of Kuntai Capsules on Sex Hormone and Blood Fat in Patients with Climacteric Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(20): 218-221.
关素珍, 蒋赟. 坤泰胶囊对更年期综合征患者性激素及血脂的影响[J]. 中国实验方剂学杂志, 2014,20(20):218-221. DOI： 10.13422/j.cnki.syfjx.2014200218.

GUAN Su-zhen, JIANG Yun. Influence of Kuntai Capsules on Sex Hormone and Blood Fat in Patients with Climacteric Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(20): 218-221. DOI： 10.13422/j.cnki.syfjx.2014200218.

摘要

目的：观察坤泰胶囊更年期综合征（CS）的疗效及对血清性激素和血脂代谢的影响。方法：86例CS患者随机按数字法分为观察组和对照组各43例。两组均给予健康教育、心理辅导、进行膳食和运动指导等基础治疗。对照组口服替勃龙片，每次2.5 mg，1次/d。观察组口服坤泰胶囊，4粒/次，3次/d。两组疗程均为12周。记录治疗前、治疗后第4，8，12周库珀曼法评分Kupperman评分（KI积分）和肝肾阴虚证评分；检测治疗前后血清雌二醇（E2）、促卵泡刺激素（FSH）、促黄体生成素（LH）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）及低密度脂蛋白胆固醇（LDL-C）水平。结果：对照组疾病总有效率为81.39%，观察组为86.04%，两组比较差异无统计学意义；治疗后第4，8，12周，两组KI评分均明显下降（P<0.01），但组间差异无统计学意义；治疗后4，8，12周观察组肝肾阴虚评分均低于对照组（P<0.01）；治疗后两组E2水平较治疗前明显升高（P<0.01），FSH，LH水平明显下降（P<0.01），治疗后组间差异无统计学意义；治疗后观察组TG，TC，LDL-C低于对照组，HDL-C高于对照组（P<0.05）；治疗后观察组TG，TC，LDL-C和HDL-C恢复正常例数多于对照组（P<0.05）。结论：坤泰胶囊在改善CS临床症状和疾病疗效方面与替勃龙片疗效相当；在升高雌二醇水平和调节脂代谢方面其疗效优于替勃龙片。

Abstract

Objective: To investigate the curative effect of Kuntai capsules and the influence on serum sex hormone and blood fat in patients with climacteric syndrome(CS). Method: Eighty-six patients with CS were randomly divided into control group and observation group of 43 patients each by random number table. Patients in both groups received basic treatment including health education

psychological guidance

dietary guidance

sport coaching

etc.Patients in control group took 2.5 mg tibolone tablets orally once daily. Patients in observation group took 4 Kuntai capsules orally 3 times daily. The patients in both groups received two 12 weeks periods of treatment. Grades of Kupperman(KI) and liver-kidney yin deficiency were recorded before and 4

8 and 12 weeks after the treatment. Levels of serous estradiol2(E2)

follicle-stimulating hormone(FSH)

luteinizing hormone(LH)

triglyceride(TG)

total cholesterol(TC)

high density lipoprotein-cholesterol(HDL-C) and low density lipoprotein-cholesterol(LDL-C) were detected before and after treatment. Result: The total curative ratewas 86.04%in observation group and 81.39% in control group with no significant difference between two groups.Scores of KI in both groups decreased(P<0.01) at 4

8 and 12 weeks after treatment

but there was no significant difference from each other. Score of liver-kidney yin deficiency in observation group was lower than that in control group(P<0.01). Level of E2 in both groups increased after treatment than before (P<0.01)

and levels of FSH

LH decreased(P<0.01)at 4

8 and 12 weeks after treatment

but there was no significant difference from each other. TG

LDL-C in observation group were lower

and HDL-C was higher than those in control group after treatment(P<0.05). The people who have normal TG

LDL-C and HDL-C levels in observation group were more than those in control group(P<0.05). Conclusion: Kuntai capsules has the same curative effect as tibolone tablets in improving clinical symptomsand treatment of patients with CS

it has higher efficacy than tibolone tablets in improving estradiol leveland regulating lipid metabolism.

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