动态优化方法对维C银翘片中牛蒡子提取时间的优化

查钦; 杨世林; 章军; 陈莎; 王跃生; 刘安

doi:10.13422/j.cnki.syfjx.2014210044

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动态优化方法对维C银翘片中牛蒡子提取时间的优化

工艺与制剂 | 更新时间：2024-01-04

- 动态优化方法对维C银翘片中牛蒡子提取时间的优化
- Application of Dynamic Optimization Method for Extraction Time of Arctii Fructus in Vitamin C Yinqiao Pian
- 中国实验方剂学杂志 2014年20卷第21期页码：44-46
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家科技支撑计划项目(2011BAI13B04)
- DOI：10.13422/j.cnki.syfjx.2014210044
  中图分类号： R282.4;R283.6;R284.2
- 纸质出版日期：2014
- 稿件说明：
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查钦, 杨世林, 章军, 等. 动态优化方法对维C银翘片中牛蒡子提取时间的优化[J]. 中国实验方剂学杂志, 2014,20(21):44-46.

ZHA Qin, YANG Shi-lin, ZHANG Jun, et al. Application of Dynamic Optimization Method for Extraction Time of Arctii Fructus in Vitamin C Yinqiao Pian[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 44-46.
查钦, 杨世林, 章军, 等. 动态优化方法对维C银翘片中牛蒡子提取时间的优化[J]. 中国实验方剂学杂志, 2014,20(21):44-46. DOI： 10.13422/j.cnki.syfjx.2014210044.

ZHA Qin, YANG Shi-lin, ZHANG Jun, et al. Application of Dynamic Optimization Method for Extraction Time of Arctii Fructus in Vitamin C Yinqiao Pian[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 44-46. DOI： 10.13422/j.cnki.syfjx.2014210044.

摘要

目的: 采用动态优化方法优选维C银翘片中牛蒡子的提取工艺。方法: 采用HPLC测定牛蒡子苷含量

检测波长280 nm

流动相乙腈-水(20:80)。通过比较动态优化工艺与原提取工艺对维C银翘片提取率、指标成分含量和指纹图谱的相似度

评价动态优化方法应用于维C银翘片中牛蒡子提取工艺优化的可行性。结果: 动态优化工艺与原提取工艺所得提取物基本一致。动态优化工艺为加8倍量60% 乙醇回流提取2次

提取时间分别为140

60 min;提取时间较原工艺节约58%

耗电量节约53%。结论: 动态优化方法可运用于维C银翘片中牛蒡子提取工艺的优化

该工艺能减少提取时间、降低能耗

具有明显的经济效益。

Abstract

Objective: To optimize extraction process of Arctii Fructus in Vitamin C Yinqiao Pian by dynamic optimization extraction method(DOEM). Method: HPLC was employed to determine the content of arctiin with detection wavelength at 280 nm and mobile phase of acetonitrile-water(20:80).Taking yield and content of arctiin

fingerprints similarity as indexes

feasibility of DOEM using in Arctii Fructus from Wei C Yinqiao tablets was evaluated

and compared with extraction process in 2010 edition of . Result: There was no difference in extract between dynamic optimization process and ordinary extraction process.Optimized DOEM was as following:reflux extracted twice with 8 times the amount of 60% ethanol for extracting time of 140 min and 60 min;it could save 58% of extraction time and 53% of power consumption. Conclusion: DOEM can be applied to optimize extraction process of Arctii Fructus in Vitamin C Yinqiao Pian

it can significantly reduce extraction time and production costs.

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