减肥中成药中非法添加酚酞的拉曼光谱快速检测

甘盛; 韩婷; 李志成; 施晓光; 吴超权

doi:10.13422/j.cnki.syfjx.2014210063

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减肥中成药中非法添加酚酞的拉曼光谱快速检测

化学与分析 | 更新时间：2024-01-04

- 减肥中成药中非法添加酚酞的拉曼光谱快速检测
- Rapid Detection of Adulterated Phenolphthalein to Chinese Pattern Diet Drugs by Raman Spectroscopy
- 中国实验方剂学杂志 2014年20卷第21期页码：63-65
- 作者机构：
- 作者简介：
- 基金信息：
  
  中国食品药品检定研究院“中青年发展研究基金”项目(2013WC3);广西自然科学青年基金项目(2014GXNSFBA118059)
- DOI：10.13422/j.cnki.syfjx.2014210063
  中图分类号： R286.0;O657.37
- 纸质出版日期：2014
- 稿件说明：
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甘盛, 韩婷, 李志成, 等. 减肥中成药中非法添加酚酞的拉曼光谱快速检测[J]. 中国实验方剂学杂志, 2014,20(21):63-65.

GAN Sheng, HAN Ting, LI Zhi-cheng, et al. Rapid Detection of Adulterated Phenolphthalein to Chinese Pattern Diet Drugs by Raman Spectroscopy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 63-65.
甘盛, 韩婷, 李志成, 等. 减肥中成药中非法添加酚酞的拉曼光谱快速检测[J]. 中国实验方剂学杂志, 2014,20(21):63-65. DOI： 10.13422/j.cnki.syfjx.2014210063.

GAN Sheng, HAN Ting, LI Zhi-cheng, et al. Rapid Detection of Adulterated Phenolphthalein to Chinese Pattern Diet Drugs by Raman Spectroscopy[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(21): 63-65. DOI： 10.13422/j.cnki.syfjx.2014210063.

摘要

目的: 研究采用拉曼光谱法快速检测减肥中成药中非法添加的酚酞。方法: 本文首先对4份减肥中成药样品各加入5 mL甲醇

超声10 min进行提取

接下来对提取液进行过滤

最后直接进行拉曼光谱的测试。结果: 建立了酚酞-甲醇溶液的标准曲线

并且对添加不同质量浓度酚酞的减肥中成药进行拉曼光谱检测

所得结果与酚酞实际添加量一致。酚酞在0.1% 以上浓度时

浓度与拉曼信号强度呈良好的线性关系(r=0.998 1)

RSD 3.7%。结论: 结合简单的前处理方法

拉曼光谱法可对减肥中成药中非法添加的酚酞进行快速筛查

并可进行定量分析;该方法快速、简便、成本低

检测限达1%

可同时得到定性与定量结果。

Abstract

Objective: To study the rapid detection of phenolphthalein content adulterated to Chinese pattern diet drugs by Raman Spectroscopy. Method: In this paper

4 portions of Chinese pattern diet drugs were extracted by 5 mL of methanol

sonicated for 10 min

then filtered and tested directly by raman spectroscopy. Result: Calibration curve was defined and analysis was performed on samples with different contents of Phenolphthalein. Results were in accordance with real amount of adulteration. The concentration of phenolphthalein and the intensity of its raman signal was in good linear at the concentration above 0.1% (r=0.998 1

RSD 3.7%). Conclusion: Samples adulterated with phenolphthalein

pretreated by a suitable method could be fast screened by raman spectroscopy. This method is fast

simple and low-cost with the detection limit at 1% for phenolphthalein. Either qualitative or quantitative results can be obtained simultaneously.

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