Objective: To discuss the effect and action mechanism of integrated Tongmai Xiaoshuan decoction and conventional western medicine on patients with deep vein thrombosis (DVT). Method: Eighty-four patients with DVT were randomly divided into observation group (42 cases) and western medicine group (42 cases) by random number table. Patients in western medicine group receivedv 5000 U low-molecular-weight heparins calcium injection (hypodermic injection) once daily

5 Bu batroxobin injection (intravenous drip) every other day

100 mg bayaspirin enteric-coated tablets once daily after dinner and 10 mL alprostadil injection (intravenous injection). Based on the treatment of western medicine group

patients in observation group added 1 dose Tongmai Xiaoshuan decoction once daily. All patients in both groups received 2 week periods of treatment. The prothrombin time (PT)

activated partial thromboplastin time (APTT)

fibrinogen (FIB)

platelet (PLT) and plasma D-two dimer(D-D)level were detected. Changes of pain

swell

sign and venous flow situation were observed

and patency of veins was detected by color Doppler flow imaging. The blood rheology target was tested before and after treatment. Result: The observation group showed a better effect than western medicine group through order information chi-square test (P<0.05). The PT

APTT

FIB

PLT and D-D levels in both groups declined compared with those before after 7 and 14 days of treatment (P<0.01). Besides

FIB and D-D levels in observation group were lower than those in western medicine group at days 7 and 14 after treatment (P<0.01). Moreover

the pain

swell

sign and venous flow situation in both groups were improved at days 7 and 14 afrer treatment compared with those before treatment (P<0.01). Besides

better effects were obtained in the observation group (P<0.01). The whole blood viscosity

plasma viscosity

blood sedimentation and whole blood reductive viscosity in both groups were improved compared with those before treatment (P<0.01). Besides

better effects were obtained in the observation group (P<0.01). Conclusion: Tongmai Xiaoshuan decoction could improve the patency of vein and relieve the symptoms and signs in patients with DVT. Its mechanism of action may be related to ameliorating blood circulation

promoting thrombolytic effects and recanalization of occluded vessels.