Premature ovarian failure (POF) is a common gynecological disease characterized with persistent amenorrhea

atrophy of sexual organ

high level follicle-stimulating hormone

high level luteinizing hormone and low level estrogen in women younger than 40 years of age These women usually have normal menarche or delayed puberty

but normal developed secondary sex characters. POF can cause infertility

aphoria and low level estrogen which seriously affects wemon's physical and mental health. Because of the increasing trend in incidence of POF

POF has become a hot and difficult topic of medical study. The main etiology

pathogenesis

syndrome differentiation of POF and traditional Chinese medicine therapies were reviewed in this paper.