Objective:By comparing activity of emulsin

the content of amygdalin in different processed products and their toxicity

to explore processing mechanism of Persicae Semen. Method: Activity of emulsin in Persicae Semen was determined by picric acid test.The content of amygdalin in different processed products was determined by HPLC

mobile phase was acetonitrile-0.1%H3PO4 and detection wavelength was set at 210 nm.Toxicity of different processed products was compared by acute toxicity experiment. Result: Crude products of Persicae Semen could make picric acid test turn red while processed products could not change.The content of amygdalin in crude products was 3.48% and significantly decreased to 2.53% after six months;the content of amygdalin in processed products(3.19%) was lower and decreased to 3.10% after six months.LD50 of water extract of processed products was 55.907 g · kg-1 which were not peeled

it was 82.943 g · kg-1 when processed products were peeled. Conclusion: Emulsin in Persicae Semen is inactivity after being processed

amygdalin is prevented from enzymolysis and loss.Toxicity of Persicae Semen is reduced after processed and peeled

processed products should be peeled to be used.This study can provide a reference for processing technology research and specification of Persicae Semen.