Objective:To investigate the effects of Buyang Huanwu Tang on lung index of pulmonary fibrosis(PF) rats induced by bleomycin (BLM). Method: Nintys healthy male SD rats were randomly divided into six groups:sham operation group

model group

prednisone group(4.2 mg · kg-1)

Buyang Huanwu Tang high-dose

middle-dose

low-dose groups(18.48

9.24

4.62 g · kg-1)

24 rats in each group. Pulmonary fibrosis model was established by injected with BLM by tracheal intubation

sham operation group was intratracheally instilled with equal NS

then every rats was raised drugs through a gastric tube one times a day. To observing general status of PF rats (such as the condition of mental

diet

hair

behavioral activity)

the changes of lung index

to measure alveolar catarrh and pulmonary fibrosis degrees in left lung dyed with HE. Result: ①Lung index:at all time points

a significant increase in lung index of model group were higher than that of sham operation group (P<0.01);other medicated groups had different decreases in lung index by comparison with model group (P<0.01);compared with the prednisone group

the lung index of Buyang Huanwu Tang middle-dose group showed an obviously decreased tendency on the 14th and 28th day (P<0.05)

this condition of that in Buyang Huanwu Tang low-dose group on the 28th day (P<0.05)

Buyang Huanwu Tang high-dose group than in prednisone group the lung index of some high at there time points

but were significantly lower than the same period in the model group. ②Pathomorphology:compared with the sham operation group

the model group and each medicated groups were mainly featured with destroyed alveoli

thickened alveoli septum and the deposition of collagen fibers on different level;the medicated groups could improve the alveolar catarrh and pulmonary fibrosis on pathomorphology in varying degree by comparison with the model group (P<0.01);the effect of reducing alveolar catarrh and pulmonary fibrosis of Buyang Huanwu Tang middle-dose group had an advantage over that of the prednisone group on the 14th and 28th day (P<0.05). Conclusion: Buyang Huanwu Tang could obviously control the growth of lung index

and alleviate alveolar catarrh and pulmonary fibrosis

the specific mechanism of that were expecting for further study.