Objective:To observe the clinical efficacy on type 2 diabetes (T2DM) treated with professor FAN Guan-jie ' s experienced prescription of Chinese medicine . Method: One hundred and twenty-eight patients according with the diagnostic criteria were randomly divided into the control group and the treatment group by random number table. Patients in treatment group (64 cases)received the treatment of Chinese medicine and patients in control group (64 cases) received the treatment of acarbose. The body mass index (BMI)

fasting blood glucose (FBG)

two hours postprandial blood glucose (2hPBG)

glycated hemoglobin(HbA1c)

total cholesterol (TC)

triglyceride (TG)

low densith lipoprotein (LDL-C)

high density lipoprotein (HDL-C)

area under insulin curve (AUCi) were observed before and after treatment. The score of traditional Chinese medicine(TCM) symptoms and signs were compared

and the the clinical efficacy was evaluated. The safety was evaluated by hepatic and renal function

and the blood routine was examination. Result: The study found that the total effective rate was 82.81% in the treatment group and 76.56% in the control group

there was no significant difference. The total effective rate in the TCM symptoms was 89.06% and 53.13% in the control group

showing significant difference (P<0.01). After the treatment

the HbA1c

FBG

2hPBG in both groups were significant improved (P<0.05

P<0.01).The BMI

AUCi

blood fat level in the treatment group were significantly improved

as compared with that in the control grou (P<0.05

P<0.01). No adverse events were found in the treatment group. Conclusion: Professor FAN Guan-jie 's experienced prescription of Chinese medicine has chear effect in treating patients with T2DM.Besides

it is beneficial in improving the clinical symptoms

losing weight

increasing the curve area of insulin and decreasing the level of blood-lipid. Therefore

it is worthy to be applied widely in clinic.