Objective:To observe the clinical effect of Huadu Yuchang decoction and its influence on nuclear transcription factor-κB (NF-κB) of intestinal mucosa

human β-defensin-2 (HBD-2) and serous proinflammatory cytokine in treating ulcerative colitis (UC) which belonged to spleen deficiency and dampness syndrome in tradition Chinese medical (TCM) syndromes. Method: Eighty patients with UC were randomly divided into control group (40 cases) and observation group (40 cases) by random number table. Patients in control group took mesalazine enter-coated tablets

to swallow not chew

1 g per time

4 times per day. Moderate patients who were in bad condition added prednisolone tablets

10 mg per time

3 times per day. Based on the treatment of control group

patients in observation group added Huadu Yuchang decoction after decocting for two times

1 dose per day

divided for 2 times. The patients in two groups received 8-week period of treatment. Scores of spleen deficiency and dampness syndrome

colonoscopy and gastric histology were graded before and after treatment. Condition of positive expression of intestinal mucosa NF-κB and HBD-2 were detected by immunohistochemistry SP method

and serous interleukin-1 (IL-1)

interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were detected. Result: After treatment

scores of spleen deficiency and dampness syndrome

colonoscopy and gastric histology in observation group were lower than those in control group (P<0.01). Condition of positive expression of intestinal mucosa NF-κB and HBD-2 in observation group were lower than those in control group (P<0.01). Levels of IL-1

IL-8 and TNF-α were lower than those in control group (P<0.01). According to ridit analysis

the comprehensive curative effect in observation group was superior to that in control group (P<0.05). Syndromes curative effect of TCM syndromes in observation group was better than that in control group (P<0.05). Conclusion: Huadu Yuchang decoction could ameliorate symptoms

improve peptic ulcer healing

and therefore had obvious clinical effect in patients with UC. Its mechanism of action may be related to inhibiting proinflammatory cytokines and protecting barrier function of intestine mucosa.