Objective:To discuss the curative efficacy of Fufang Xuduan Jiegu pills on limbs fracture healing and the influence on bone morphogenetic protein (BMP)

insulin-like growth factor (IGF) and vascular endothelial growth factor (VEGF). Method: Ninety patients were randomly divided into control group (45 cases) and observation group (45 cases) by random number table. Patients in control group received one alfacalcidol twice daily and patients in observation group received one Fufang Xuduan Jiegu pills twice daily for 6 weeks. The disappeared times of pain

swelling and ecchymosis in two groups were recorded. The growth of callus was observed using X-ray. The levels of BMP

IGF and VEGF were detected before and after treatment. Result: The healing efficacy of clinical fractures in observation group was superior to that in control group (P<0.05) through ridit analysis. The disappeared times of pain

swelling and ecchymosis in observation group were shorter than those in control group (P<0.01). Callus growth score in observation group was higher than that in control group at the sixth and eighth week after treatment (P<0.01). Levels of BMP-2

IGF-I

IGF-Ⅱand VEGF in observation group were superior to those in control group (P<0.01). Conclusion: Fufang Xuduan Jiegu pills could promote the formation of callus and the healing of fracture. The action mechanism may be achieved by accelerating the expression of BMP-2

IGF-I

IGF-Ⅱ and VEGF.