Objective: To optimize formulation process of auraptene dispersible tablets and evaluate its in vitro dissolution. Method: With angle of repose

hardness and disintegration time as indexes

effects of cross-linking polyvinyl pyrrolidone(PVPP)

microcrystalline cellulose(MCC)

pregelatinized starch(PRS)

low substituted hydroxypropyl cellulose(L-HPC)

sodium carboxymethyl starch(CMS-Na) and other excipients on formulation process were investigated.In vitro dissolution of dispersible tablets was determined by HPLC

mobile phase of methanol-water(95: 5)

detection wavelength was set at 325 nm. Result: Optimal formula was as follows:auraptene 10 g

MCC 40 g

L-HPC 20 g

PVPP 10 g

CSM-Na 20 g

PRS 30 g

amylum 20 g;dispersible tablets disintegrated uniformly in 1 min

cumulative dissolution of this drug was more than 85% within 30 min. Conclusion: These prepared auraptene dispersible tablets have a fast

homogeneously dispersing profile and good releasing characteristics

which is suitable for clinical application.