Objective: To optimize alcohol and water extraction processes of Zhiyu granules

in order to provide a reference for commercial production of this preparation. Method: HPLC was employed to determine the content of geniposide with mobile phase of acetonitrile-water(10: 90) and detection wavelength at 238 nm;taking yield of geniposide as index

orthogonal test was adopted to optimize alcohol extraction process with extracting time

extracting times

ethanol concentration and amount as factors.The content of total polysaccharides by UV

detection wavelength was set at 490 nm;orthogonal test was used to optimize water extraction process by taking yield of total polysaccharides as index

the amount of water

extraction time and times as factors. Result: Optimum extraction technology of Zhiyu granules was as following:extracted twice with 6 times the amount of 70% ethanol for 1.0 h of per time

then medicine residue extracted thrice with 10 times the amount of water for 2.0 hours of each time;yields of geniposide and total polysaccharides were 0.013 29 and 0.030 39 g· g-1. Conclusion: This optimized process is reliable and feasible with high extraction rate of effective components.