Objective: To observe the preventive effects of Xuesaitong and Ginaton injection on cerebral ischemia reperfusion(I/R) injury in rats. Method: Hundred and thirty SD male rats were divided into low dosage (25 mg· kg-1) and high dosage (50 mg· kg-1)

of Xuesaitong and Ginaton injection

sham-operation and model groups.The volume of cerebral infarction

behavioral score

weight

mortality

superoxide dismutase(SOD)

malondialdehyde(MDA)

glutathione-S-transferase(GSH-S-transferase)

nitrogen oxide(NO)

NO synthase(NOS)

xanthine oxidase(XOD)

C-reactive proein(CRP) were determined to evaluate preventive effect. Result: Low Xuesaitong dosage had no effect on volume of cerebral infarction

behavioral score at 4

24 h

mortality

SOD

GSH

NO and NOS

but it could reduce MDA content significantly. High Xuesaitong dosage had no effect on behavioral score at 4 h

mortality

SOD

MDA

NO

NOS

CRP

but it could reduce behavioral score at 24 h

volume of cerebral infarction

GSH. The low Ginaton dosage had no effect on weight

behavioral score at 4

24 h

mortality

MDA

SOD

GSH

NOS

but it could reduce volume of cerebral infarction

NO content significantly;the high dosage had no effect on MDA

SOD

GSH

NO

CRP. It could reduce behavioral score at 4

24 h

volume of cerebral infarction

NOS and XOD activities significantly. Conclusion: The high dose Xuesaitong and Ginaton might be more effective than low dosage in reducing cerebral ischemia reperfusion injury. No significant difference was observed between Xuesaitong and Ginaton in a same dosage.