Objective: To discuss the influence of Qizhi Weitong granules and Muxiang Shunqi pills combined with omeprazole magnesium enteric-coated tablets and itopride hydrochloride tablets on esophageal motility and acid reflux in patients with gastroesophageal reflux disease (GERD). Method: Ninety GERD patients were randomly divided into western medicine group (45 cases) and observation group (45 cases) by random number table. Patients in western medicine group took 20 mg omeprazole magnesium enteric-coated tablets orally morning and night and 50 mg itopride hydrochloride tablets 3 times daily. Based on the treatment of western medicine group

patients in observation group added 5 g Qizhi Weitong particle 3 times daily

and 6 g Muxiang Shunqi pills 3 times daily. All patients in two groups received 8-week course of treatmen. Score of reflux disease questionnaire (RDQ) scale was recorded before and after the treatment. Esophageal manometry and 24 h esophageal pH monitoring were conducted. Result: The resting pressure of upper and lower esophageal sphincter in both groups were increased after treatment. Besides

the observation group obtained better results (P<0.01). Success rate of wet swallowing in both groups was increased as compared with that before

and the success rate in observation group was higher than that in western medicine group (P<0.01). The total number of acid reflux

the number of acid reflux>5 min

the percentage of total pH 4

the percentage of decubitus pH<4

the longest reflux time and DeMeester score in observation group were decreased after treatment (P<0.01). Besides

total number of acid reflux and DeMeester score in observation group were less than those in western medicine group (P<0.01). RDQ scale heartburn

reflux

non cardiac chest pain

anti acid score and total score in observation group were inferior to those in western medicine group (P<0.01). Conclusion: Integrated traditional Chinese medicine and western medicine therapy can strengthen function of esophageal peristalsis

improve esophageal motility

reduce acid reflux

and relieve GERD symptoms. The curative effect of this therapy is superior to using western medicine treatment alone.