Objective: To optimize preparation process of children anti-sweating granules and provide a reference for clinical application of this preparation. Method: UV was adopted to determine the content of total saponins with detection wavelength of 541 nm.Children anti-sweating granules was prepared by extrusion granulation method

with total saponin content and dissolving time as comprehensive evaluation index

orthogonal test was adopted to optimize preparation process by taking water extraction time

alcohol precipitation concentration

ratio of dextrin-extract as factors

quality of this preparation was evaluated. Result: Optimal preparation process was as following:water extraction for 5 h

alcohol precipitation volume fraction of 60%

extract-dextrin(1:1.5);three batches of these granules had uniform particle size with brown

slightly sweet taste and consistent color

without moisture absorption

caking and deliquescence phenomenon.Dissolving time of these granules was 194 s

moisture content was 4.75%

the content of total saponins was 56.13 mg·g-1. Conclusion: This preparation process is stable

repeatable and feasible for children anti-sweating granules.