Objective: The purpose of this research was to evaluate the performance of Daidai flavones self-microemulsifying pellets

and to establish a method for the determination of Daidai flavones in this preparation. Method: The performance was evaluated by appearance

size distribution

droplet size

self-emulsification efficiency

zeta potential

stability and influence factors after forming micro emulsion. The neohesperidin was used as index ingredient

and the content of total flavones was measured by UV-sectrophotometry at 284 nm. Result: The size of Daidai flavones SME pellets in this research mainly distributed at 16-30 sieves and the yield reached up to 92.43%

the end product was uniformly spherical yellowish-brown pellets. The droplet sizes after forming micro emulsion were nearly the same as those in different dispersion mediums

at different rotate speeds and at different temperatures. The average diameter of Daidai flavones SME pellets were (78.8±12) nm. The UV method for determination of total flavones content was established. The linear ranges of neohesperidin was 4.44-26.64 mg·L-1 (r=0.999 9) with the average recoveries of 99.9% (RSD 1.0%). Conclusion: The Daidai flavones self-microemulsifying pellets have good self-microemulsifying performance. The UV method is simple

accurate and reliable

can be well used for the determination of total flavones in Daidai flavones self-microemulsifying pellets.