Objective: The aim of this study was to establish a method for the content determination of chlorogenic acid

liquiritin

hesperidin

arctiin and phillyrin in Yinqiao Powder. Method: UPLC system was performed on ACQUITY UPLC BEH Shield RP18 column(2.1 mm×50 mm

1.7 μm)at 40 ℃. The mobile phase was consisted of methanol-0.15% formic acid solution in gradient elution mode. The flow rate was set at 0.25 mL·min-1 and the detection wavelength was set at 279 nm. Result: Chlorogenic acid

phillyrin

arctiin

hesperidin and liquiritin had good linear relationship in the ranges of 0.018 76-0.043 77

0.002 370-0.011 85

0.011 21-0.056 06

0.001 34-0.006 71 and 0.001 71-0.012 38 μg

respectively. The corre-lation coefficients were all more than 0.999 1.The average recoveries were 97.12%(RSD 0.9%)

101.40%(RSD 2.1%)

100.61%(RSD 1.6%)

100.79%(RSD 0.7%)and 101.04%(RSD 1.7%)

respectively. Conclusion: The method is simple

rapid

specific

and can be used for quality control of Yinqiao powder.