Objective: To observe the effect and mechanism of Shuwei decoction on gastrointestinal motility and gastrointestinal nerve-interstitial cells of Cajal-smooth muscle (ENS-ICC-SMC) network ultrastructure

to investigate in functional dyspepsia (functional dyspepsia

FD) with liver and spleen deficiency rats. Method: Seventy-two rats were randomly divided into normal group

model group

the low

middle and high dose groups of Shuwei decoction (7.67

15.34

30.68 g·kg-1)

mosapride group (1.37 mg·kg-1)

12 rats in each group.The model was made bychronic restraint stress combined with fatigue and improper diet. Three day after modeling corresponding drug

were give once daily for 14 days.The residual rate of stomach

small intestine propulsion rate were detected and to the structure of ENS-ICC-SMC network of gastric antrum and duodenum tissue were observed under electron microscope. Result: Compared with the control group

model group delayed gastric emptying

increased the gastric emptying rate

intestinal propulsion rate(P<0.05). Compared with the model group

treatment groups had significantly lower gastric emptying rate

and increased intestinal propulsion rate significantly (P<0.01). Compared with the model group

treatment groups improved ICC cells

ICC peripheral nerve endand relationship between ICC and ICC and between smooth muscle cells. Conclusion: Shuwei decoction can improve the relationship between the ultrastructure of ENS-ICC-SMC network

and improve the gastrointestinal motility

which is effective in the treatment of FD.