Objective: To study the effect of Ailuo Kechuanning on mitogen activatein kinase(p38MAPK)

myeloperoxidase(MPO)

interleukin-17(IL-17)

C-reactive protein(CRP)

and oxidative stress in rats with chronic obstructive pulmonary disease (COPD). Method: Lipopolysaccharide(LPS) smoke wasused to COPD rat model

the experimental animals were randomly divided into normal group

model group

Ailuo Kechuanning groups(7.75

15.52

31.04 g·kg-1·d-1)

The activity of p-p38MAPK and MPO was detected by colorimetric method

enzyme-linked immunosorbent assay was used to determine the change of IL-17 and C-reactive protein(CRP) levels.the concentration of MDA

the activity of SOD and glutethione peroxiadase(GSH-Px) were measured in lung homogenates of all the groups. Result: The activity of p-p38MAPK and MPO

the levels of IL-17 and CRP were higher significantly

the activity of SOD and GSH-Px were decreased

the level of MDA was higher significantly in lung homogenates of the model group. Compared with the normal control group. While the activity of p-p38MAPK and MPO

and the levels of IL-17 and CRP was decreased significantly.the activity of SOD and GSH-Px were higher significantly

and the level of MDA was decreased significantly in lung homogenates of the rats treated with Ailuo Kechuanning(15.52 g·kg-1·d-1)compared with the model group. Conclusion: Ailuo Kechuanning may improve the pulmonary function of COPD. The effects of Ailuo Kechuanning for treatment of COPD may inhibite the activity of p-p38MAPK and MPO

and decrease the levels of IL-17

CRP and MDA

lead to the anti-inflammatory and against oxidative damage.