Objective: To study the antioxidant effect of Lycium ruthenicum buccal tablet in mice. Method: Fourty mice were randomly divided into 4 group:normal group (normal saline) low-and high-dose L. ruthenicum buccal tablet groups (0.08

0.16 mg·g-1)

and vitamin C group (0.02 mg·g-1). The mice were sacrificed by intragastric administration 28 days later and the total antioxidant capacity (T-AOC)

the contents of malondialdehyde (MDA)

the activities of superoxide dismutase (SOD)

glutathione peroxidase enzyme (GSH-Px) and catalase (CAT) in serum and liver were determined using the test kits. Result: Compared with normal group

no significant changes were found in the mice body weight

while the contents of MDA in serum and liver was significantly decreased are (5.97±2.53)

(11.08±3.72) μmol·L-1 and (5.84±1.44)

(10.79±2.06) μmol·L-1(P<0.05

P<0.01)

the activities of T-AOC

SOD

GSH-Px and CAT were significantly increased (P<0.05 or P<0.01) in high-and low-dose L. ruthenicum buccal tablet groups. Conclusion: L. ruthenicum buccal tablet has significant antioxidant activity in vivo.